WHY MACHINE LANGUAGE

Interpretation or compiling of HOLs: Both cost time in an already computationally intensive process.
Closure with HOLs (i.e., dealing with the data typing problem): Operations in HOLs require variables, constants, function arguments and function return values to be consistent.
HOLs exist for the benefit of the human programmer, not the machine. If the human isn't in the detailed code development process, HOLs may not be necessary.
Machine language (binary) is the 'native representation' of CPU and related hardware instructions.
ML eliminates the closure problem.
ML is a flexible representation for genetic manipulation processes.